7LMO

Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 34 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-7-(1H-imidazole-5-carbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione]

7LMO の概要

• エントリーDOI: 10.2210/pdb7lmo/pdb
• 分子名称: JTO light chain, PHOSPHATE ION, (5~{R})-3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-7-(1~{H}-imidazol-4-ylcarbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione, ... (4 entities in total)
• 機能のキーワード: amyloidosis, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47119.58

構造登録者

Yan, N.L.,Wilson, I.A.,Kelly, J.W. (登録日: 2021-02-05, 公開日: 2021-05-19, 最終更新日: 2023-10-18)

• 主引用文献: Yan, N.L.,Santos-Martins, D.,Nair, R.,Chu, A.,Wilson, I.A.,Johnson, K.A.,Forli, S.,Morgan, G.J.,Petrassi, H.M.,Kelly, J.W.; Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.; J.Med.Chem., 64:6273-6299, 2021; PubMed: 33939422; DOI: 10.1021/acs.jmedchem.1c00339

実験手法

X-RAY DIFFRACTION (1.99 Å)