7LL5

High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.

Summary for 7LL5

• Entry DOI: 10.2210/pdb7ll5/pdb
• Descriptor: Tyrosine-protein kinase JAK2, 1,2-ETHANEDIOL, {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, ... (4 entities in total)
• Functional Keywords: rheumatoid arthritis, innate immuninity, adaptive immunity, myeloproliferative neoplasms, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35120.13

Authors

Karim, M.R.,Schonbrunn, E. (deposition date: 2021-02-03, release date: 2022-01-12, Last modification date: 2024-11-20)

• Primary citation: Karim, M.R.,Schonbrunn, E.; High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-150.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)