7LKY

Crystal Structure of PHF1 Tudor domain in complex with a peptidomimetic ligand UNC6641

7LKY の概要

• エントリーDOI: 10.2210/pdb7lky/pdb
• 分子名称: Isoform 1 of PHD finger protein 1, Peptidomimetic inhibitor UNC6641, ZINC ION, ... (5 entities in total)
• 機能のキーワード: epigenetic reader, peptidomimetic inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 66294.61

構造登録者

Liu, J.,Kutateladze, T.G. (登録日: 2021-02-03, 公開日: 2021-12-15, 最終更新日: 2023-10-18)

• 主引用文献: Engelberg, I.A.,Liu, J.,Norris-Drouin, J.L.,Cholensky, S.H.,Ottavi, S.A.,Frye, S.V.,Kutateladze, T.G.,James, L.I.; Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1).; J.Med.Chem., 64:8510-8522, 2021; PubMed: 33999620; DOI: 10.1021/acs.jmedchem.1c00430

実験手法

X-RAY DIFFRACTION (1.85 Å)