7LK0
Ornithine Aminotransferase (OAT) cocrystallized with its potent inhibitor - (S)-3-amino-4,4-difluorocyclopent-1-enecarboxylic acid (SS-1-148)
Summary for 7LK0
Entry DOI | 10.2210/pdb7lk0/pdb |
Descriptor | Ornithine aminotransferase, mitochondrial, (1R,3S)-3-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-oxocyclopentane-1-carboxylic acid (3 entities in total) |
Functional Keywords | ornithine aminotransferase, oat, aminotransferase, inhibitor, inactivator, ss-1-148, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 3 |
Total formula weight | 135697.76 |
Authors | Butrin, A.,Shen, S.,Liu, D.,Silverman, R. (deposition date: 2021-02-01, release date: 2022-02-16, Last modification date: 2023-10-18) |
Primary citation | Shen, S.,Butrin, A.,Doubleday, P.F.,Melani, R.D.,Beaupre, B.A.,Tavares, M.T.,Ferreira, G.M.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B. Turnover and Inactivation Mechanisms for ( S )-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. J.Am.Chem.Soc., 143:8689-8703, 2021 Cited by PubMed: 34097381DOI: 10.1021/jacs.1c02456 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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