7LJT

Porcine Dihydropyrimidine Dehydrogenase (DPD) soaked with 5-Ethynyluracil (5EU), NADPH - 20 minutes

Summary for 7LJT

• Entry DOI: 10.2210/pdb7ljt/pdb
• Descriptor: Dihydropyrimidine dehydrogenase [NADP(+)], IRON/SULFUR CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: dihydropyrimidine dehydrogenase, dpd, dehydrogenase, 5-ethynyluracil, 5eu, inhibitor, inactivator, flavoprotein
• Biological source: Sus scrofa (Pig)
• Total number of polymer chains: 4
• Total formula weight: 460525.24

Authors

Butrin, A.,Forouzesh, D.,Beaupre, B.,Wawrzak, Z.,Liu, D.,Moran, G. (deposition date: 2021-01-30, release date: 2021-04-07, Last modification date: 2023-10-18)

• Primary citation: Forouzesh, D.C.,Beaupre, B.A.,Butrin, A.,Wawrzak, Z.,Liu, D.,Moran, G.R.; The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil.; Biochemistry, 60:1120-1132, 2021; PubMed: 33755421; DOI: 10.1021/acs.biochem.1c00096

Experimental method

X-RAY DIFFRACTION (1.98 Å)