7LJT
Porcine Dihydropyrimidine Dehydrogenase (DPD) soaked with 5-Ethynyluracil (5EU), NADPH - 20 minutes
Summary for 7LJT
Entry DOI | 10.2210/pdb7ljt/pdb |
Descriptor | Dihydropyrimidine dehydrogenase [NADP(+)], IRON/SULFUR CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | dihydropyrimidine dehydrogenase, dpd, dehydrogenase, 5-ethynyluracil, 5eu, inhibitor, inactivator, flavoprotein |
Biological source | Sus scrofa (Pig) |
Total number of polymer chains | 4 |
Total formula weight | 460525.24 |
Authors | Butrin, A.,Forouzesh, D.,Beaupre, B.,Wawrzak, Z.,Liu, D.,Moran, G. (deposition date: 2021-01-30, release date: 2021-04-07, Last modification date: 2023-10-18) |
Primary citation | Forouzesh, D.C.,Beaupre, B.A.,Butrin, A.,Wawrzak, Z.,Liu, D.,Moran, G.R. The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil. Biochemistry, 60:1120-1132, 2021 Cited by PubMed: 33755421DOI: 10.1021/acs.biochem.1c00096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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