7LJE
Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
7LJE の概要
エントリーDOI | 10.2210/pdb7lje/pdb |
分子名称 | Histone acetyltransferase p300, 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methyl-acetamide (3 entities in total) |
機能のキーワード | histone acetylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 163518.22 |
構造登録者 | |
主引用文献 | Ji, Z.,Clark, R.F.,Bhat, V.,Matthew Hansen, T.,Lasko, L.M.,Bromberg, K.D.,Manaves, V.,Algire, M.,Martin, R.,Qiu, W.,Torrent, M.,Jakob, C.G.,Liu, H.,Cole, P.A.,Marmorstein, R.,Kesicki, E.A.,Lai, A.,Michaelides, M.R. Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases. Bioorg.Med.Chem.Lett., 39:127854-127854, 2021 Cited by PubMed: 33631370DOI: 10.1016/j.bmcl.2021.127854 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.607 Å) |
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