7LHZ
K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and (3S)-10-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-9-fluoro-3-methyl-5-oxo-2,3-dihydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid (compound 25)
7LHZ の概要
エントリーDOI | 10.2210/pdb7lhz/pdb |
分子名称 | DNA topoisomerase 4 subunit B, DNA topoisomerase 4 subunit A chimera, DNA (5'-D(P*TP*AP*CP*GP*TP*TP*GP*TP*AP*T)-3'), DNA (5'-D(*GP*AP*TP*CP*AP*TP*AP*CP*AP*AP*CP*GP*TP*AP*A)-3'), ... (7 entities in total) |
機能のキーワード | gyrase, dna topoisomerase, parc, pare, isomerase-dna-inhibitor complex, isomerase/dna/inhibitor |
由来する生物種 | Klebsiella pneumoniae 342 詳細 |
タンパク質・核酸の鎖数 | 12 |
化学式量合計 | 370442.11 |
構造登録者 | |
主引用文献 | Lapointe, G.,Skepper, C.K.,Holder, L.M.,Armstrong, D.,Bellamacina, C.,Blais, J.,Bussiere, D.,Bian, J.,Cepura, C.,Chan, H.,Dean, C.R.,De Pascale, G.,Dhumale, B.,Fisher, L.M.,Fulsunder, M.,Kantariya, B.,Kim, J.,King, S.,Kossy, L.,Kulkarni, U.,Lakshman, J.,Leeds, J.A.,Ling, X.,Lvov, A.,Ma, S.,Malekar, S.,McKenney, D.,Mergo, W.,Metzger, L.,Mhaske, K.,Moser, H.E.,Mostafavi, M.,Namballa, S.,Noeske, J.,Osborne, C.,Patel, A.,Patel, D.,Patel, T.,Piechon, P.,Polyakov, V.,Prajapati, K.,Prosen, K.R.,Reck, F.,Richie, D.L.,Sanderson, M.R.,Satasia, S.,Savani, B.,Selvarajah, J.,Sethuraman, V.,Shu, W.,Tashiro, K.,Thompson, K.V.,Vaarla, K.,Vala, L.,Veselkov, D.A.,Vo, J.,Vora, B.,Wagner, T.,Wedel, L.,Williams, S.L.,Yendluri, S.,Yue, Q.,Yifru, A.,Zhang, Y.,Rivkin, A. Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria. J.Med.Chem., 64:6329-6357, 2021 Cited by PubMed: 33929852DOI: 10.1021/acs.jmedchem.1c00375 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.3 Å) |
構造検証レポート
検証レポート(詳細版)
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