7LFH
Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)
Summary for 7LFH
Entry DOI | 10.2210/pdb7lfh/pdb |
EMDB information | 23302 23303 23304 23305 |
Descriptor | NACHT, LRR and PYD domains-containing protein 3 (1 entity in total) |
Functional Keywords | nlrp3, nek7, nucleotid-binding, atp-binding, inflammasome, immunity, innate immunity, nacht, lrr, pyd, immune system |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 12 |
Total formula weight | 1425626.63 |
Authors | Andreeva, L.,Rawson, S.,Wu, H. (deposition date: 2021-01-17, release date: 2021-12-15, Last modification date: 2024-05-29) |
Primary citation | Andreeva, L.,David, L.,Rawson, S.,Shen, C.,Pasricha, T.,Pelegrin, P.,Wu, H. NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell, 184:6299-, 2021 Cited by PubMed: 34861190DOI: 10.1016/j.cell.2021.11.011 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.2 Å) |
Structure validation
Download full validation report