7LEN

Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose

Summary for 7LEN

Entry DOI	10.2210/pdb7len/pdb
Descriptor	Isoform 4 of Epidermal growth factor receptor, Proepiregulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	receptor, epiregulin, glioblastoma, cancer, mutation, extracellular, asymmetric, dimer, erbb1, egfr, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	127324.11
Authors	Hu, C.,Leche II, C.A.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A. (deposition date: 2021-01-14, release date: 2021-11-17, Last modification date: 2023-10-18)
Primary citation	Hu, C.,Leche 2nd, C.A.,Kiyatkin, A.,Yu, Z.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A. Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature, 602:518-522, 2022 Cited by PubMed: 35140400 DOI: 10.1038/s41586-021-04393-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation