7LD4

Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist

7LD4 の概要

• エントリーDOI: 10.2210/pdb7ld4/pdb
• EMDBエントリー: 23281
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: signaling protein, membrane protein, active-state g protein-coupled receptor, adenosine a1 receptor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130426.33

構造登録者

Draper-Joyce, C.J.,Danev, R.,Thal, D.M.,Christopoulos, A.,Glukhova, A. (登録日: 2021-01-12, 公開日: 2021-09-08, 最終更新日: 2021-10-13)

• 主引用文献: Draper-Joyce, C.J.,Bhola, R.,Wang, J.,Bhattarai, A.,Nguyen, A.T.N.,Cowie-Kent, I.,O'Sullivan, K.,Chia, L.Y.,Venugopal, H.,Valant, C.,Thal, D.M.,Wootten, D.,Panel, N.,Carlsson, J.,Christie, M.J.,White, P.J.,Scammells, P.,May, L.T.,Sexton, P.M.,Danev, R.,Miao, Y.,Glukhova, A.,Imlach, W.L.,Christopoulos, A.; Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia.; Nature, 597:571-576, 2021; PubMed: 34497422; DOI: 10.1038/s41586-021-03897-2

実験手法

ELECTRON MICROSCOPY (3.3 Å)