7LCQ
N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease
Summary for 7LCQ
Entry DOI | 10.2210/pdb7lcq/pdb |
Descriptor | 3C-like proteinase, 1,2-ETHANEDIOL, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, ... (4 entities in total) |
Functional Keywords | covid-19, sars-cov-1, 3clpro, coronavirus, main protease, kinetics, sars, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus (SARS-CoV) |
Total number of polymer chains | 1 |
Total formula weight | 34406.26 |
Authors | Khan, M.B.,Arutyunova, E.,Young, H.S.,Lemieux, M.J. (deposition date: 2021-01-11, release date: 2021-05-12, Last modification date: 2023-10-18) |
Primary citation | Arutyunova, E.,Khan, M.B.,Fischer, C.,Lu, J.,Lamer, T.,Vuong, W.,van Belkum, M.J.,McKay, R.T.,Tyrrell, D.L.,Vederas, J.C.,Young, H.S.,Lemieux, M.J. N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 M pro Dimer. J.Mol.Biol., 433:167003-167003, 2021 Cited by PubMed: 33895266DOI: 10.1016/j.jmb.2021.167003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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