7LCP

N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease

Summary for 7LCP

• Entry DOI: 10.2210/pdb7lcp/pdb
• Descriptor: 3C-like proteinase, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: covid-19, sars-cov-2, 3clpro, coronavirus, main protease, kinetics, sars, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus (SARS-CoV)
• Total number of polymer chains: 1
• Total formula weight: 34464.43

Authors

Khan, M.B.,Arutyunova, E.,Young, H.S.,Lemieux, M.J. (deposition date: 2021-01-11, release date: 2021-05-12, Last modification date: 2023-10-18)

• Primary citation: Arutyunova, E.,Khan, M.B.,Fischer, C.,Lu, J.,Lamer, T.,Vuong, W.,van Belkum, M.J.,McKay, R.T.,Tyrrell, D.L.,Vederas, J.C.,Young, H.S.,Lemieux, M.J.; N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 M pro Dimer.; J.Mol.Biol., 433:167003-167003, 2021; PubMed: 33895266; DOI: 10.1016/j.jmb.2021.167003

Experimental method

X-RAY DIFFRACTION (1.9 Å)