7LBC

Structure of human GGT1 in complex with Lnt2-65 compound

7LBC の概要

• エントリーDOI: 10.2210/pdb7lbc/pdb
• 分子名称: Glutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: substrate-enzyme complex, ntn-hydrolase family, glycoprotein, n-glycosylation, cell surface, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60011.12

構造登録者

Terzyan, S.S.,Hanigan, M. (登録日: 2021-01-07, 公開日: 2022-02-09, 最終更新日: 2023-10-18)

• 主引用文献: Nguyen, L.,Schultz, D.C.,Terzyan, S.S.,Rezaei, M.,Songb, J.,Li, C.,You, Y.,Hanigan, M.H.; Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase.; Bioorg.Med.Chem., 73:116986-116986, 2022; PubMed: 36208545; DOI: 10.1016/j.bmc.2022.116986

実験手法

X-RAY DIFFRACTION (2.28 Å)