7LAF
15-lipoxygenase-2 loop mutant bound to imidazole-based inhibitor
Summary for 7LAF
Entry DOI | 10.2210/pdb7laf/pdb |
Descriptor | Polyunsaturated fatty acid lipoxygenase ALOX15B, MANGANESE (II) ION, 3-{[(4-methylphenyl)methyl]sulfanyl}-1-phenyl-1H-1,2,4-triazole, ... (4 entities in total) |
Functional Keywords | lipoxygenase, inhibitor, allostery, complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, lipid binding protein, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 155422.47 |
Authors | Newcomer, M.E.,Gilbert, N.C.,Neau, D.B. (deposition date: 2021-01-06, release date: 2022-01-19, Last modification date: 2023-10-18) |
Primary citation | Tsai, W.C.,Gilbert, N.C.,Ohler, A.,Armstrong, M.,Perry, S.,Kalyanaraman, C.,Yasgar, A.,Rai, G.,Simeonov, A.,Jadhav, A.,Standley, M.,Lee, H.W.,Crews, P.,Iavarone, A.T.,Jacobson, M.P.,Neau, D.B.,Offenbacher, A.R.,Newcomer, M.,Holman, T.R. Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2. Bioorg.Med.Chem., 46:116349-116349, 2021 Cited by PubMed: 34500187DOI: 10.1016/j.bmc.2021.116349 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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