7L7B

Clostridioides difficile RNAP with fidaxomicin

Summary for 7L7B

Entry DOI	10.2210/pdb7l7b/pdb
EMDB information	23210
Descriptor	DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (9 entities in total)
Functional Keywords	fidaxomicin, clostridioides difficile rna polymerase, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological source	Clostridia bacterium More
Total number of polymer chains	6
Total formula weight	398105.85
Authors	Boyaci, H.,Campbell, E.A.,Darst, S.A.,Chen, J. (deposition date: 2020-12-28, release date: 2022-02-02, Last modification date: 2024-05-29)
Primary citation	Cao, X.,Boyaci, H.,Chen, J.,Bao, Y.,Landick, R.,Campbell, E.A. Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604:541-545, 2022 Cited by PubMed: 35388215 DOI: 10.1038/s41586-022-04545-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.26 Å)

Structure validation