7L7B
Clostridioides difficile RNAP with fidaxomicin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA-directed RNA polymerase subunit alpha | polymer | 315 | 34958.9 | 2 | UniProt (Q18CI5) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) | Clostridia bacterium | RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha |
| 2 | C (C) | DNA-directed RNA polymerase subunit beta | polymer | 1266 | 142367.4 | 1 | UniProt (Q18CF1) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) | Clostridia bacterium | RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta |
| 3 | D (D) | DNA-directed RNA polymerase subunit beta' | polymer | 1161 | 129916.4 | 1 | UniProt (Q18CF3) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) | Clostridia bacterium | RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta' |
| 4 | E (E) | DNA-directed RNA polymerase subunit omega | polymer | 88 | 10214.5 | 1 | UniProt (Q182S6) Pfam (PF01192) | Clostridia bacterium | RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega |
| 5 | F (F) | RNA polymerase sigma factor SigA | polymer | 390 | 44476.6 | 1 | UniProt (A0A500XEZ5) Pfam (PF03979) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) UniProt (by SIFTS) (Q18BX5) | Clostridia bacterium | |
| 6 | G, H (D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | I (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 8 | J (D) | Fidaxomicin | non-polymer | 1058.0 | 1 | Chemie (FI8) PubChem (23305223) PubChem (151383) PubChem (20284238) PubChem (44609697) PubChem (46174142) PubChem (57747794) PubChem (59008169) PubChem (59828312) PubChem (58925621) PubChem (58871626) PubChem (59185390) PubChem (59828307) PubChem (70678896) PubChem (177436649) PubChem (177505840) PubChem (177675128) PubChem (177675577) PubChem (89818117) PubChem (90711861) PubChem (71433506) PubChem (71735471) PubChem (91455983) PubChem (9941472) PubChem (75905631) PubChem (89251739) PubChem (89818116) PubChem (90770916) PubChem (90804732) PubChem (90749848) PubChem (91193162) PubChem (91363790) PubChem (91441582) PubChem (91885501) PubChem (101607192) PubChem (117590639) PubChem (102580518) PubChem (118555468) PubChem (6440191) PubChem (123506604) PubChem (123816381) PubChem (9963335) PubChem (10034073) PubChem (129134564) PubChem (131668620) PubChem (132285157) PubChem (132472265) PubChem (132980491) PubChem (11528171) PubChem (134545906) PubChem (143727492) PubChem (137650947) PubChem (129010003) PubChem (129010263) PubChem (138976139) PubChem (138991594) PubChem (138977122) PubChem (129897224) PubChem (13858643) PubChem (15942712) PubChem (135391138) PubChem (156022379) PubChem (156610556) PubChem (162861842) PubChem (164170938) PubChem (138107160) PubChem (168311742) PubChem (168311806) PubChem (168317477) PubChem (168313228) PubChem (168317457) PubChem (154805964) PubChem (171137781) PubChem (171669603) PubChem (171705409) PubChem (162861840) PubChem (162861841) | |||
| 9 | K, L, M, N, O... (A, B, C, D, E...) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
C: 2 - 1238 (UniProt: Q18CF1)
F: 0 - 388 (UniProt: A0A500XEZ5)
| PDB | External Database | Details |
|---|---|---|
| Met -27 | - | initiating methionine |
| Trp -26 | - | expression tag |
| Ser -25 | - | expression tag |
| His -24 | - | expression tag |
| Pro -23 | - | expression tag |
| Gln -22 | - | expression tag |
| Phe -21 | - | expression tag |
| Glu -20 | - | expression tag |
| Lys -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Trp -6 | - | expression tag |
| Ser -5 | - | expression tag |
| His -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Lys 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 396892.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1213.2 | |
| All* | Total formula weight | 398105.9 |
