7L7B
Clostridioides difficile RNAP with fidaxomicin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA-directed RNA polymerase subunit alpha | polymer | 315 | 34958.9 | 2 | UniProt (Q18CI5) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) | Clostridia bacterium | RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha |
| 2 | C (C) | DNA-directed RNA polymerase subunit beta | polymer | 1266 | 142367.4 | 1 | UniProt (Q18CF1) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) | Clostridia bacterium | RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta |
| 3 | D (D) | DNA-directed RNA polymerase subunit beta' | polymer | 1161 | 129916.4 | 1 | UniProt (Q18CF3) Pfam (PF04997) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) | Clostridia bacterium | RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta' |
| 4 | E (E) | DNA-directed RNA polymerase subunit omega | polymer | 88 | 10214.5 | 1 | UniProt (Q182S6) Pfam (PF01192) | Clostridia bacterium | RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega |
| 5 | F (F) | RNA polymerase sigma factor SigA | polymer | 390 | 44476.6 | 1 | UniProt (A0A500XEZ5) Pfam (PF03979) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) UniProt (by SIFTS) (Q18BX5) | Clostridia bacterium | |
| 6 | G, H (D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | I (D) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 8 | J (D) | Fidaxomicin | non-polymer | 1058.0 | 1 | Chemie (FI8) | |||
| 9 | K, L, M, N, O... (A, B, C, D, E...) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
C: 2 - 1238 (UniProt: Q18CF1)
F: 0 - 388 (UniProt: A0A500XEZ5)
| PDB | External Database | Details |
|---|---|---|
| Met -27 | - | initiating methionine |
| Trp -26 | - | expression tag |
| Ser -25 | - | expression tag |
| His -24 | - | expression tag |
| Pro -23 | - | expression tag |
| Gln -22 | - | expression tag |
| Phe -21 | - | expression tag |
| Glu -20 | - | expression tag |
| Lys -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Gly -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Gly -14 | - | expression tag |
| Gly -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Trp -6 | - | expression tag |
| Ser -5 | - | expression tag |
| His -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Phe -1 | - | expression tag |
| Glu 0 | - | expression tag |
| Lys 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 396892.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1213.2 | |
| All* | Total formula weight | 398105.9 |
