7L72

Crystal structure of the second bromodomain (BD2) of human BRD3 bound to Ro3280

7L72 の概要

• エントリーDOI: 10.2210/pdb7l72/pdb
• 分子名称: Bromodomain-containing protein 3, 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide (3 entities in total)
• 機能のキーワード: bet, plk1, epigenetics, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13851.01

構造登録者

Karim, M.R.,Bikowitz, M.,Schonbrunn, E. (登録日: 2020-12-25, 公開日: 2021-11-17, 最終更新日: 2023-10-18)

• 主引用文献: Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E.; Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.; J.Med.Chem., 64:15772-15786, 2021; PubMed: 34710325; DOI: 10.1021/acs.jmedchem.1c01096

実験手法

X-RAY DIFFRACTION (1.5 Å)