7L4X

YTH Domain of Human YTHDC1 with dsDNA Comprising Single N6mA joined by two six-bp DNA duplexes in P3221 Crystal

7L4X の概要

• エントリーDOI: 10.2210/pdb7l4x/pdb
• 分子名称: YTH domain-containing protein 1, ssDNA w/N6A, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: n6-methyladenine binding protein domain, ssdna, dna binding protein, protein-dna complex, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23000.66

構造登録者

Horton, J.R.,Cheng, X. (登録日: 2020-12-21, 公開日: 2021-11-03, 最終更新日: 2023-10-18)

• 主引用文献: Yu, D.,Horton, J.R.,Yang, J.,Hajian, T.,Vedadi, M.,Sagum, C.A.,Bedford, M.T.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions.; Nucleic Acids Res., 49:11629-11642, 2021; PubMed: 34086966; DOI: 10.1093/nar/gkab460

実験手法

X-RAY DIFFRACTION (1.79 Å)