7L29
Crystal structure of the catalytic domain of human PDE3A bound to AMP
Summary for 7L29
Entry DOI | 10.2210/pdb7l29/pdb |
Descriptor | cGMP-inhibited 3',5'-cyclic phosphodiesterase A, ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, ... (7 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 174658.59 |
Authors | Horner, S.W.,Garvie, C. (deposition date: 2020-12-16, release date: 2021-06-16, Last modification date: 2024-04-03) |
Primary citation | Garvie, C.W.,Wu, X.,Papanastasiou, M.,Lee, S.,Fuller, J.,Schnitzler, G.R.,Horner, S.W.,Baker, A.,Zhang, T.,Mullahoo, J.P.,Westlake, L.,Hoyt, S.H.,Toetzl, M.,Ranaghan, M.J.,de Waal, L.,McGaunn, J.,Kaplan, B.,Piccioni, F.,Yang, X.,Lange, M.,Tersteegen, A.,Raymond, D.,Lewis, T.A.,Carr, S.A.,Cherniack, A.D.,Lemke, C.T.,Meyerson, M.,Greulich, H. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun, 12:4375-4375, 2021 Cited by PubMed: 34272366DOI: 10.1038/s41467-021-24495-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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