7L29
Crystal structure of the catalytic domain of human PDE3A bound to AMP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | polymer | 380 | 43169.1 | 4 | UniProt (Q14432) Pfam (PF00233) In PDB | Homo sapiens (Human) | Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A,Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A,Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A |
2 | A, B, C, D | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) | |||
3 | A, B, C, D | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
4 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
6 | A, B, C, D | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
7 | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 669 - 779 (UniProt: Q14432)
A, B, C, D: 801 - 1061 (UniProt: Q14432)
A, B, C, D: 1068 - 1095 (UniProt: Q14432)
PDB | External Database | Details |
---|---|---|
Gly 668 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 780 | - | linker |
Gly 796 | - | linker |
Ser 797 | - | linker |
Gly 798 | - | linker |
Gly 799 | - | linker |
Ser 800 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 1062 | - | linker |
Gly 1063 | - | linker |
Ser 1064 | - | linker |
Gly 1065 | - | linker |
Gly 1066 | - | linker |
Ser 1067 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 172676.5 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 1982.1 | |
All* | Total formula weight | 174658.6 |