7L29
Crystal structure of the catalytic domain of human PDE3A bound to AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cGMP-inhibited 3',5'-cyclic phosphodiesterase A | polymer | 380 | 43169.1 | 4 | UniProt (Q14432) Pfam (PF00233) | Homo sapiens (Human) | Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A,Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A,Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A |
| 2 | E, J, N, R (A, B, C, D) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) | |||
| 3 | F, K, O, S (A, B, C, D) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 4 | G, L, P, T (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | H (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | I, M, Q, U (A, B, C, D) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 7 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 669 - 779 (UniProt: Q14432)
A, B, C, D: 801 - 1061 (UniProt: Q14432)
A, B, C, D: 1068 - 1095 (UniProt: Q14432)
| PDB | External Database | Details |
|---|---|---|
| Gly 668 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 780 | - | linker |
| Gly 796 | - | linker |
| Ser 797 | - | linker |
| Gly 798 | - | linker |
| Gly 799 | - | linker |
| Ser 800 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 1062 | - | linker |
| Gly 1063 | - | linker |
| Ser 1064 | - | linker |
| Gly 1065 | - | linker |
| Gly 1066 | - | linker |
| Ser 1067 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 172676.5 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1982.1 | |
| All* | Total formula weight | 174658.6 |
