7L24
HPK1 IN COMPLEX WITH COMPOUND 11
Summary for 7L24
Entry DOI | 10.2210/pdb7l24/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, 6-(2-fluoro-6-methoxyphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1H-pyrazolo[4,3-c]pyridine (3 entities in total) |
Functional Keywords | hpk1 hematopoietic progenitor kinase, inhibitor complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 131012.74 |
Authors | Lesburg, C.A. (deposition date: 2020-12-16, release date: 2021-03-17, Last modification date: 2024-04-03) |
Primary citation | Yu, E.C.,Methot, J.L.,Fradera, X.,Lesburg, C.A.,Lacey, B.M.,Siliphaivanh, P.,Liu, P.,Smith, D.M.,Xu, Z.,Piesvaux, J.A.,Kawamura, S.,Xu, H.,Miller, J.R.,Bittinger, M.,Pasternak, A. Identification of Potent Reverse Indazole Inhibitors for HPK1. Acs Med.Chem.Lett., 12:459-466, 2021 Cited by PubMed: 33738073DOI: 10.1021/acsmedchemlett.0c00672 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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