7L1X

Structure of human CK2 alpha kinase (catalytic subunit) with the inhibitor 108600.

7L1X の概要

• エントリーDOI: 10.2210/pdb7l1x/pdb
• 分子名称: Casein kinase II subunit alpha, SULFATE ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: inhibitor 108600, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40950.29

構造登録者

Rechkoblit, O.,Aggarwal, A.K. (登録日: 2020-12-15, 公開日: 2021-08-11, 最終更新日: 2023-10-18)

• 主引用文献: Sato, K.,Padgaonkar, A.A.,Baker, S.J.,Cosenza, S.C.,Rechkoblit, O.,Subbaiah, D.R.C.V.,Domingo-Domenech, J.,Bartkowski, A.,Port, E.R.,Aggarwal, A.K.,Ramana Reddy, M.V.,Irie, H.Y.,Premkumar Reddy, E.; Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.; Nat Commun, 12:4671-4671, 2021; PubMed: 34344863; DOI: 10.1038/s41467-021-24878-z

実験手法

X-RAY DIFFRACTION (1.8 Å)