7L1A

Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)

7L1A の概要

• エントリーDOI: 10.2210/pdb7l1a/pdb
• 分子名称: S-adenosylmethionine synthase isoform type-2, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total)
• 機能のキーワード: s-adenosylmethionine, sam synthetase, enzyme mechanism, inhibitor, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47149.43

構造登録者

Niland, C.N.,Fedorov, E.,Schramm, V.L.,Ghosh, A. (登録日: 2020-12-14, 公開日: 2021-03-17, 最終更新日: 2023-10-18)

• 主引用文献: Niland, C.N.,Ghosh, A.,Cahill, S.M.,Schramm, V.L.; Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A.; Biochemistry, 60:791-801, 2021; PubMed: 33656855; DOI: 10.1021/acs.biochem.0c00998

実験手法

X-RAY DIFFRACTION (1.25 Å)