7L0N

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

7L0N の概要

• エントリーDOI: 10.2210/pdb7l0n/pdb
• 分子名称: Monoclonal antibody S309 Fab light chain, SULFATE ION, SODIUM ION, ... (17 entities in total)
• 機能のキーワード: covid-19, sars-cov-2, variant rbd, viral protein-receptor complex, viral protein, viral protein-hydrolase complex, viral protein/hydrolase
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 380023.63

構造登録者

Snell, G.,Czudnochowski, N.,Dillen, J.,Nix, J.C.,Croll, T.I.,Corti, D. (登録日: 2020-12-11, 公開日: 2021-02-17, 最終更新日: 2023-10-18)

• 主引用文献: Thomson, E.C.,Rosen, L.E.,Shepherd, J.G.,Spreafico, R.,da Silva Filipe, A.,Wojcechowskyj, J.A.,Davis, C.,Piccoli, L.,Pascall, D.J.,Dillen, J.,Lytras, S.,Czudnochowski, N.,Shah, R.,Meury, M.,Jesudason, N.,De Marco, A.,Li, K.,Bassi, J.,O'Toole, A.,Pinto, D.,Colquhoun, R.M.,Culap, K.,Jackson, B.,Zatta, F.,Rambaut, A.,Jaconi, S.,Sreenu, V.B.,Nix, J.,Zhang, I.,Jarrett, R.F.,Glass, W.G.,Beltramello, M.,Nomikou, K.,Pizzuto, M.,Tong, L.,Cameroni, E.,Croll, T.I.,Johnson, N.,Di Iulio, J.,Wickenhagen, A.,Ceschi, A.,Harbison, A.M.,Mair, D.,Ferrari, P.,Smollett, K.,Sallusto, F.,Carmichael, S.,Garzoni, C.,Nichols, J.,Galli, M.,Hughes, J.,Riva, A.,Ho, A.,Schiuma, M.,Semple, M.G.,Openshaw, P.J.M.,Fadda, E.,Baillie, J.K.,Chodera, J.D.,Rihn, S.J.,Lycett, S.J.,Virgin, H.W.,Telenti, A.,Corti, D.,Robertson, D.L.,Snell, G.; Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.; Cell, 184:1171-1187.e20, 2021; PubMed: 33621484; DOI: 10.1016/j.cell.2021.01.037

実験手法

X-RAY DIFFRACTION (2.78 Å)