7L0E

Crystal structure of bovine RPE65 in complex with gem-difluoro emixustat and palmitate

Summary for 7L0E

Entry DOI	10.2210/pdb7l0e/pdb
Descriptor	Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (6 entities in total)
Functional Keywords	non-heme iron, beta propeller, isomerohydrolase, isomerase, monotopic membrane protein, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Bos taurus (Bovine)
Total number of polymer chains	2
Total formula weight	123398.61
Authors	Kiser, P.D. (deposition date: 2020-12-11, release date: 2021-06-02, Last modification date: 2023-10-18)
Primary citation	Blum, E.,Zhang, J.,Zaluski, J.,Einstein, D.E.,Korshin, E.E.,Kubas, A.,Gruzman, A.,Tochtrop, G.P.,Kiser, P.D.,Palczewski, K. Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J.Med.Chem., 64:8287-8302, 2021 Cited by PubMed: 34081480 DOI: 10.1021/acs.jmedchem.1c00279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation