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7L03

The aminoacrylate form of the wild-type Salmonella typhimurium Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the enzyme alpha-site and sodium ion at the metal coordination site at 1.60 Angstrom resolution. Three water molecules are close to the amynoacrylate at the enzyme beta-site

Summary for 7L03
Entry DOI10.2210/pdb7l03/pdb
Related4HN4 6D0V 6VNT 6X0C 7KA1 7KQ9 7KWV
DescriptorTryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (8 entities in total)
Functional Keywordsinhibitor, lyase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceSalmonella enterica subsp. enterica serovar Typhimurium
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Total number of polymer chains2
Total formula weight72906.74
Authors
Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-12-11, release date: 2021-12-22, Last modification date: 2023-10-18)
Primary citationHilario, E.,Dunn, M.F.,Mueller, L.J.
The aminoacrylate form of the wild-type Salmonella typhimurium Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the enzyme alpha-site and sodium ion at the metal coordination site at 1.60 Angstrom resolution. Three water molecules are close to the amynoacrylate at the enzyme beta-site.
To be Published,
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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