7KZ0

Human MBD4 glycosylase domain bound to DNA containing substrate analog 2'-deoxy-pseudouridine

Summary for 7KZ0

• Entry DOI: 10.2210/pdb7kz0/pdb
• Descriptor: Methyl-CpG-binding domain protein 4, DNA (5'-D(*CP*CP*AP*GP*CP*GP*(P2U)P*GP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*CP*GP*CP*GP*CP*TP*GP*G)-3'), ... (6 entities in total)
• Functional Keywords: mbd4, protein-dna complex, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 28205.74

Authors

Pidugu, L.S.,Pozharski, E.,Drohat, A.C. (deposition date: 2020-12-09, release date: 2021-11-10, Last modification date: 2023-10-18)

• Primary citation: Pidugu, L.S.,Bright, H.,Lin, W.J.,Majumdar, C.,Van Ostrand, R.P.,David, S.S.,Pozharski, E.,Drohat, A.C.; Structural Insights into the Mechanism of Base Excision by MBD4.; J.Mol.Biol., 433:167097-167097, 2021; PubMed: 34107280; DOI: 10.1016/j.jmb.2021.167097

Experimental method

X-RAY DIFFRACTION (1.57 Å)