7KX6

Crystal structure of DCLK1-KD in complex with XMD8-85

7KX6 の概要

• エントリーDOI: 10.2210/pdb7kx6/pdb
• 分子名称: Serine/threonine-protein kinase DCLK1, 2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total)
• 機能のキーワード: kinase, doublecortin-like, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63518.57

構造登録者

Patel, O.,Lucet, I. (登録日: 2020-12-03, 公開日: 2021-09-22, 最終更新日: 2023-10-18)

• 主引用文献: Patel, O.,Roy, M.J.,Kropp, A.,Hardy, J.M.,Dai, W.,Lucet, I.S.; Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.; Commun Biol, 4:1105-1105, 2021; PubMed: 34545159; DOI: 10.1038/s42003-021-02631-y

実験手法

X-RAY DIFFRACTION (2.5 Å)