7KWU

Crystal Structure of HIV-1 RT in Complex with 16c (K07-15)

Summary for 7KWU

Entry DOI	10.2210/pdb7kwu/pdb
Descriptor	Reverse transcriptase p66, Reverse transcriptase p51, SULFATE ION, ... (7 entities in total)
Functional Keywords	human immunodeficiency virus 1, non nucleotide-reverse transcriptase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1) More
Total number of polymer chains	2
Total formula weight	115530.42
Authors	Ruiz, F.X.,Arnold, E. (deposition date: 2020-12-02, release date: 2021-03-31, Last modification date: 2023-10-18)
Primary citation	Kang, D.,Ruiz, F.X.,Sun, Y.,Feng, D.,Jing, L.,Wang, Z.,Zhang, T.,Gao, S.,Sun, L.,De Clercq, E.,Pannecouque, C.,Arnold, E.,Zhan, P.,Liu, X. 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. J.Med.Chem., 64:4239-4256, 2021 Cited by PubMed: 33734714 DOI: 10.1021/acs.jmedchem.1c00268 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation