7KU7
Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. Cluster identified by 3-dimensional variability analysis in cryoSPARC.
Summary for 7KU7
Entry DOI | 10.2210/pdb7ku7/pdb |
EMDB information | 22400 23035 |
Descriptor | integrase, DNA (5'-D(*AP*AP*TP*GP*TP*TP*GP*TP*CP*TP*TP*AP*TP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*AP*TP*TP*GP*CP*AP*TP*AP*AP*GP*AP*CP*AP*AP*CP*A)-3'), ... (6 entities in total) |
Functional Keywords | intasome, integrase-viral dna complex, hydrolase-dna-inhibitor complex, hydrolase/dna/inhibitor |
Biological source | Rous sarcoma virus (strain Schmidt-Ruppin A) (RSV-PrC) More |
Total number of polymer chains | 12 |
Total formula weight | 269404.11 |
Authors | Pandey, K.K.,Bera, S.,Shi, K.,Aihara, H.,Grandgenett, D.P. (deposition date: 2020-11-24, release date: 2021-03-17, Last modification date: 2024-03-06) |
Primary citation | Pandey, K.K.,Bera, S.,Shi, K.,Rau, M.J.,Oleru, A.V.,Fitzpatrick, J.A.J.,Engelman, A.N.,Aihara, H.,Grandgenett, D.P. Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol, 4:330-330, 2021 Cited by PubMed: 33712691DOI: 10.1038/s42003-021-01855-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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