7KR3
Human DNA Ligase 1(E346A/E592A) Bound to a bulged DNA substrate
Summary for 7KR3
Entry DOI | 10.2210/pdb7kr3/pdb |
Descriptor | DNA ligase 1, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*CP*C)-3'), DNA (5'-D(P*AP*TP*TP*CP*TP*GP*C)-3'), ... (7 entities in total) |
Functional Keywords | dna ligase, dna replication, dna repair, replication, fidelity, ligase, ligase-dna complex, ligase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 83598.89 |
Authors | Tumbale, P.P.,Williams, R.S. (deposition date: 2020-11-18, release date: 2021-02-03, Last modification date: 2023-10-18) |
Primary citation | Williams, J.S.,Tumbale, P.P.,Arana, M.E.,Rana, J.A.,Williams, R.S.,Kunkel, T.A. High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication. Nat Commun, 12:482-482, 2021 Cited by PubMed: 33473124DOI: 10.1038/s41467-020-20800-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.778 Å) |
Structure validation
Download full validation report