7KQL

Anti-Tim3 antibody Fab complex

Summary for 7KQL

Entry DOI	10.2210/pdb7kql/pdb
Descriptor	Tim3.18 Fab heavy chain, Tim3.18 Fab light chain, Hepatitis A virus cellular receptor 2, ... (5 entities in total)
Functional Keywords	tim3 havcr2 fab antibody, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	63236.56
Authors	Deng, X.A.,West, S.M.,Strop, P. (deposition date: 2020-11-16, release date: 2022-02-09, Last modification date: 2023-10-18)
Primary citation	Pagliano, O.,Morrison, R.M.,Chauvin, J.M.,Banerjee, H.,Davar, D.,Ding, Q.,Tanegashima, T.,Gao, W.,Chakka, S.R.,DeBlasio, R.,Lowin, A.,Kara, K.,Ka, M.,Zidi, B.,Amin, R.,Raphael, I.,Zhang, S.,Watkins, S.C.,Sander, C.,Kirkwood, J.M.,Bosenberg, M.,Anderson, A.C.,Kuchroo, V.K.,Kane, L.P.,Korman, A.J.,Rajpal, A.,West, S.M.,Han, M.,Bee, C.,Deng, X.,Schebye, X.M.,Strop, P.,Zarour, H.M. Tim-3 mediates T cell trogocytosis to limit antitumor immunity. J.Clin.Invest., 132:-, 2022 Cited by PubMed: 35316223 DOI: 10.1172/JCI152864 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation