7KPU

Crystal structure of human NatD (NAA40) bound to a bisubstrate analogue with a C-3 linker

Summary for 7KPU

• Entry DOI: 10.2210/pdb7kpu/pdb
• Descriptor: N-alpha-acetyltransferase 40, bisubstrate analogue (CMC-ACE-SER-GLY-ARG-GLY-LYS), SULFATE ION, ... (9 entities in total)
• Functional Keywords: acetyl transferase, naa40, natd, bisubstrate, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 51056.05

Authors

Deng, S.,Marmorstein, R. (deposition date: 2020-11-12, release date: 2021-06-16, Last modification date: 2023-10-18)

• Primary citation: Deng, Y.,Deng, S.,Ho, Y.H.,Gardner, S.M.,Huang, Z.,Marmorstein, R.,Huang, R.; Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.; J.Med.Chem., 64:8263-8271, 2021; PubMed: 34110812; DOI: 10.1021/acs.jmedchem.1c00141

Experimental method

X-RAY DIFFRACTION (1.43 Å)