7KP6

Structure of Ack1 kinase in complex with a selective inhibitor

7KP6 の概要

• エントリーDOI: 10.2210/pdb7kp6/pdb
• 分子名称: Activated CDC42 kinase 1, 5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, tyrosine kinase, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65867.64

構造登録者

Thakur, M.K.,Miller, W.T.,Mahajan, N.,Seeliger, M.A. (登録日: 2020-11-10, 公開日: 2022-02-09, 最終更新日: 2023-10-25)

• 主引用文献: Sridaran, D.,Chouhan, S.,Mahajan, K.,Renganathan, A.,Weimholt, C.,Bhagwat, S.,Reimers, M.,Kim, E.H.,Thakur, M.K.,Saeed, M.A.,Pachynski, R.K.,Seeliger, M.A.,Miller, W.T.,Feng, F.Y.,Mahajan, N.P.; Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance.; Nat Commun, 13:6929-6929, 2022; PubMed: 36376335; DOI: 10.1038/s41467-022-34724-5

実験手法

X-RAY DIFFRACTION (1.79 Å)