7KL6

Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase

7KL6 の概要

• エントリーDOI: 10.2210/pdb7kl6/pdb
• 分子名称: Phosphoribosyltransferase, (3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl)phosphonic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: helicobacter pylori xanthine-guanine-hypoxanthine phosphoribosyltransferase drug discovery nucleoside phosphonates, transferase
• 由来する生物種: Helicobacter pylori
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37598.78

構造登録者

Guddat, L.W.,Keough, D.T. (登録日: 2020-10-29, 公開日: 2021-05-05, 最終更新日: 2024-03-06)

• 主引用文献: Keough, D.T.,Wun, S.J.,Baszczynski, O.,Eng, W.S.,Spacek, P.,Panjikar, S.,Naesens, L.,Pohl, R.,Rejman, D.,Hockova, D.,Ferrero, R.L.,Guddat, L.W.; Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.; J.Med.Chem., 64:5710-5729, 2021; PubMed: 33891818; DOI: 10.1021/acs.jmedchem.0c02184

実験手法

X-RAY DIFFRACTION (1.97 Å)