7KK4
Structure of the catalytic domain of PARP1 in complex with olaparib
Summary for 7KK4
Entry DOI | 10.2210/pdb7kk4/pdb |
Descriptor | Poly [ADP-ribose] polymerase 1, 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one (3 entities in total) |
Functional Keywords | parp1, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 79550.90 |
Authors | Gajiwala, K.S.,Ryan, K. (deposition date: 2020-10-27, release date: 2021-01-06, Last modification date: 2023-10-18) |
Primary citation | Ryan, K.,Bolanos, B.,Smith, M.,Palde, P.B.,Cuenca, P.D.,VanArsdale, T.L.,Niessen, S.,Zhang, L.,Behenna, D.,Ornelas, M.A.,Tran, K.T.,Kaiser, S.,Lum, L.,Stewart, A.,Gajiwala, K.S. Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1. J.Biol.Chem., 296:100251-100251, 2021 Cited by PubMed: 33361107DOI: 10.1074/jbc.RA120.016573 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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