7KHY

Crystal structure of OXA-163 K73A in complex with meropenem

Summary for 7KHY

Entry DOI	10.2210/pdb7khy/pdb
Related	7KHQ
Descriptor	Beta-lactamase, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
Functional Keywords	beta-lactamase, carbapenemase, beta-lactamase inhibitor, complex, oxacillinase, hydrolase, hydrolase-hydrolase inhibitor complex
Biological source	Enterobacter cloacae
Total number of polymer chains	1
Total formula weight	28430.75
Authors	Palzkill, T.,Hu, L.,Sankaran, B.,Prasad, B.V.V. (deposition date: 2020-10-22, release date: 2021-02-10, Last modification date: 2023-10-18)
Primary citation	Stojanoski, V.,Hu, L.,Sankaran, B.,Wang, F.,Tao, P.,Prasad, B.V.V.,Palzkill, T. Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems. Acs Infect Dis., 7:445-460, 2021 Cited by PubMed: 33492952 DOI: 10.1021/acsinfecdis.0c00798 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation