7KER

avibactam-CDD-1 45 minute complex

Summary for 7KER

• Entry DOI: 10.2210/pdb7ker/pdb
• Descriptor: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, (2S,5R)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, ... (7 entities in total)
• Functional Keywords: antibiotic resistance, mutant, gram-positive, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Clostridioides difficile
• Total number of polymer chains: 1
• Total formula weight: 37412.35

Authors

Smith, C.A.,Vakulenko, S.B.,Stewart, N.K.,Toth, M. (deposition date: 2020-10-12, release date: 2021-01-20, Last modification date: 2021-05-26)

• Primary citation: Stewart, N.K.,Toth, M.,Stasyuk, A.,Lee, M.,Smith, C.A.,Vakulenko, S.B.; Inhibition of the Clostridioides difficile Class D beta-Lactamase CDD-1 by Avibactam.; Acs Infect Dis., 7:1164-1176, 2021; PubMed: 33390002; DOI: 10.1021/acsinfecdis.0c00714

Experimental method

X-RAY DIFFRACTION (1.93 Å)