7KEH

Crystal structure from SARS-CoV-2 NendoU NSP15

7KEH の概要

• エントリーDOI: 10.2210/pdb7keh/pdb
• 分子名称: Uridylate-specific endoribonuclease, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: nsp15, nendou, covid-19, covid, sars, sars-cov-2, endoribonuclease, viral protein, hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2, COVID-19 virus)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78981.86

構造登録者

Godoy, A.S.,Nakamura, A.M.,Pereira, H.M.,Noske, G.D.,Gawriljuk, V.O.,Fernandes, R.S.,Oliveira, K.I.Z.,Oliva, G. (登録日: 2020-10-10, 公開日: 2020-12-02, 最終更新日: 2023-10-25)

• 主引用文献: Godoy, A.S.,Nakamura, A.M.,Douangamath, A.,Song, Y.,Noske, G.D.,Gawriljuk, V.O.,Fernandes, R.S.,Pereira, H.D.M.,Oliveira, K.I.Z.,Fearon, D.,Dias, A.,Krojer, T.,Fairhead, M.,Powell, A.,Dunnet, L.,Brandao-Neto, J.,Skyner, R.,Chalk, R.,Bajusz, D.,Bege, M.,Borbas, A.,Keseru, G.M.,von Delft, F.,Oliva, G.; Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.; Nucleic Acids Res., 2023; PubMed: 37115000; DOI: 10.1093/nar/gkad314

実験手法

X-RAY DIFFRACTION (2.59 Å)