7KDY

Crystal structure of Streptomyces tokunonesis TokK with hydroxycobalamin, 5'-deoxyadenosine, methionine, and (2R)-pantetheinylated carbapenam

7KDY の概要

• エントリーDOI: 10.2210/pdb7kdy/pdb
• 分子名称: Methyltransferase TokK, IRON/SULFUR CLUSTER, COBALAMIN, ... (9 entities in total)
• 機能のキーワード: radical sam, cobalamin, [4fe-4s] cluster, fes cluster, methyltransferase, b12, beta-lactam antibiotic synthesis, transferase
• 由来する生物種: Streptomyces tokunonensis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 159854.23

構造登録者

Knox, H.L.,Booker, S.J.,Boal, A.K. (登録日: 2020-10-09, 公開日: 2022-01-12, 最終更新日: 2024-04-03)

• 主引用文献: Knox, H.L.,Sinner, E.K.,Townsend, C.A.,Boal, A.K.,Booker, S.J.; Structure of a B 12 -dependent radical SAM enzyme in carbapenem biosynthesis.; Nature, 602:343-348, 2022; PubMed: 35110734; DOI: 10.1038/s41586-021-04392-4

実験手法

X-RAY DIFFRACTION (1.939 Å)