7KCX
Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with cefoxitin
Summary for 7KCX
Entry DOI | 10.2210/pdb7kcx/pdb |
Descriptor | Penicillin-binding protein 4, (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | acyl-enzyme intermediate, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Staphylococcus aureus (strain COL) |
Total number of polymer chains | 1 |
Total formula weight | 41672.34 |
Authors | Alexander, J.A.N.,Strynadka, N.C.J. (deposition date: 2020-10-07, release date: 2021-06-30, Last modification date: 2023-10-18) |
Primary citation | Satishkumar, N.,Alexander, J.A.N.,Poon, R.,Buggeln, E.,Argudin, M.A.,Strynadka, N.C.J.,Chatterjee, S.S. PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus. J.Antimicrob.Chemother., 76:2268-2272, 2021 Cited by PubMed: 34151961DOI: 10.1093/jac/dkab201 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)