7KAC

Crystal structure of HPK1 (MAP4K1) kinase in complex with 5-{[4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]AMINO}-5-(1,3,4-OXADIAZOL-2-YL)PYRIMIDIN-2-YL]AMINO}-3,3-DIMETHYL-2-BENZOFURAN-1(3H)-ONE

Summary for 7KAC

• Entry DOI: 10.2210/pdb7kac/pdb
• Descriptor: Isoform 2 of Mitogen-activated protein kinase kinase kinase kinase 1, 5-{[4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino}-3,3-dimethyl-2-benzofuran-1(3H)-one (3 entities in total)
• Functional Keywords: kinase, map4k1, hpk1, serine/threonine-protein kinase, hematopoietic progenitor kinase, mapk/erk kinase kinase kinase 1, mek kinase kinase 1, mekkk1, nucleotide-binding, phosphoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 77024.58

Authors

Sheriff, S. (deposition date: 2020-09-30, release date: 2021-01-13, Last modification date: 2023-10-18)

• Primary citation: Lau, W.L.,Pearce, B.,Malakian, H.,Rodrigo, I.,Xie, D.,Gao, M.,Marsilio, F.,Chang, C.,Ruzanov, M.,Muckelbauer, J.K.,Newitt, J.A.,Lipovsek, D.,Sheriff, S.; Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).; Acta Crystallogr.,Sect.F, 77:22-28, 2021; PubMed: 33439152; DOI: 10.1107/S2053230X20016015

Experimental method

X-RAY DIFFRACTION (1.85 Å)