7KA1

1.60 Angstrom resolution crystal structure of the beta-Q114A mutant Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, aminoacrylate at the beta site, and cesium ion at the metal coordination site

Summary for 7KA1

• Entry DOI: 10.2210/pdb7ka1/pdb
• Related: 4HN4 4HPX 6D0V 6X0C
• Descriptor: Tryptophan synthase alpha chain, DI(HYDROXYETHYL)ETHER, Tryptophan synthase beta chain, ... (11 entities in total)
• Functional Keywords: lyase, inhibitor, tryptophan synthase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); More
• Total number of polymer chains: 2
• Total formula weight: 74749.13

Authors

Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-09-29, release date: 2021-09-29, Last modification date: 2023-10-18)

• Primary citation: Hilario, E.,Dunn, M.F.,Mueller, L.J.; 1.60 Angstrom resolution crystal structure of the beta-Q114A mutant Tryptophan Synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, aminoacrylate at the beta site, and cesium ion at the metal coordination site.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)