7K9R
Cryptococcus neoformans Hsp90 nucleotide binding domain
Summary for 7K9R
Entry DOI | 10.2210/pdb7k9r/pdb |
Descriptor | Hsp90-like protein, CHLORIDE ION (3 entities in total) |
Functional Keywords | crytococcus neoformans, hsp90 atp-binding, chaperone |
Biological source | Cryptococcus neoformans |
Total number of polymer chains | 3 |
Total formula weight | 72026.21 |
Authors | Kuntz, D.A.,Kenney, T.,Prive, G.G. (deposition date: 2020-09-29, release date: 2021-01-27, Last modification date: 2023-10-18) |
Primary citation | Marcyk, P.T.,LeBlanc, E.V.,Kuntz, D.A.,Xue, A.,Ortiz, F.,Trilles, R.,Bengtson, S.,Kenney, T.M.G.,Huang, D.S.,Robbins, N.,Williams, N.S.,Krysan, D.J.,Prive, G.G.,Whitesell, L.,Cowen, L.E.,Brown, L.E. Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. J.Med.Chem., 64:1139-1169, 2021 Cited by PubMed: 33444025DOI: 10.1021/acs.jmedchem.0c01777 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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