7K8G

Crystal structure of bovine RPE65 in complex with 4-fluoro-MB-004 and palmitate

7K8G の概要

• エントリーDOI: 10.2210/pdb7k8g/pdb
• 分子名称: Retinoid isomerohydrolase, FE (II) ION, PALMITIC ACID, ... (5 entities in total)
• 機能のキーワード: non-heme iron, inhibitor, beta propeller, isomerase, isomerohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Bos taurus (Bovine)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123089.43

構造登録者

Kiser, P.D. (登録日: 2020-09-27, 公開日: 2021-06-02, 最終更新日: 2023-10-18)

• 主引用文献: Blum, E.,Zhang, J.,Zaluski, J.,Einstein, D.E.,Korshin, E.E.,Kubas, A.,Gruzman, A.,Tochtrop, G.P.,Kiser, P.D.,Palczewski, K.; Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.; J.Med.Chem., 64:8287-8302, 2021; PubMed: 34081480; DOI: 10.1021/acs.jmedchem.1c00279

実験手法

X-RAY DIFFRACTION (1.95 Å)