7K88

Crystal structure of bovine RPE65 in complex with hexaethylene glycol monooctyl ether

Summary for 7K88

• Entry DOI: 10.2210/pdb7k88/pdb
• Descriptor: Retinoid isomerohydrolase, FE (II) ION, 3,6,9,12,15,18-hexaoxahexacosan-1-ol, ... (6 entities in total)
• Functional Keywords: non-heme iron, isomerohydrolase, c8e6, inhibitor, beta-propeller, isomerase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Bos taurus (Bovine)
• Total number of polymer chains: 2
• Total formula weight: 122988.07

Authors

Kiser, P.D. (deposition date: 2020-09-26, release date: 2021-06-02, Last modification date: 2023-10-18)

• Primary citation: Blum, E.,Zhang, J.,Zaluski, J.,Einstein, D.E.,Korshin, E.E.,Kubas, A.,Gruzman, A.,Tochtrop, G.P.,Kiser, P.D.,Palczewski, K.; Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.; J.Med.Chem., 64:8287-8302, 2021; PubMed: 34081480; DOI: 10.1021/acs.jmedchem.1c00279

Experimental method

X-RAY DIFFRACTION (2.1 Å)