7K62
Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218
Summary for 7K62
Entry DOI | 10.2210/pdb7k62/pdb |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (5 entities in total) |
Functional Keywords | ssgcid, tetrahydrofolate biosynthesis, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium kansasii |
Total number of polymer chains | 2 |
Total formula weight | 39805.80 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-09-18, release date: 2021-03-17, Last modification date: 2023-10-18) |
Primary citation | Abendroth, J.,Dranow, D.M.,Santhakumar, V.,Walpole, C.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E. Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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