7K62

Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218

7K62 の概要

• エントリーDOI: 10.2210/pdb7k62/pdb
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, ... (5 entities in total)
• 機能のキーワード: ssgcid, tetrahydrofolate biosynthesis, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium kansasii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39805.80

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2020-09-18, 公開日: 2021-03-17, 最終更新日: 2023-10-18)

• 主引用文献: Abendroth, J.,Dranow, D.M.,Santhakumar, V.,Walpole, C.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal Structure of Dihydrofolate reductase from Mycobacterium kansasii in complex with NADP and inhibitor P218; To Be Published,

実験手法

X-RAY DIFFRACTION (2.05 Å)