7K4M

Crystal structure of MetAP2 Modified Hemoglobin S

Summary for 7K4M

• Entry DOI: 10.2210/pdb7k4m/pdb
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (5 entities in total)
• Functional Keywords: hemoglobin s, inhibitor, antisickling, oxygen transport
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 162911.96

Authors

Musayev, F.N.,Safo, M.K.,Light, D.R. (deposition date: 2020-09-15, release date: 2021-10-13, Last modification date: 2023-10-18)

• Primary citation: Demers, M.,Sturtevant, S.,Guertin, K.R.,Gupta, D.,Desai, K.,Vieira, B.F.,Li, W.,Hicks, A.,Ismail, A.,Goncalves, B.P.,Di Caprio, G.,Schonbrun, E.,Hansen, S.,Musayev, F.N.,Safo, M.K.,Wood, D.K.,Higgins, J.M.,Light, D.R.; MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.; Blood Adv, 5:1388-1402, 2021; PubMed: 33661300; DOI: 10.1182/bloodadvances.2020003670

Experimental method

X-RAY DIFFRACTION (2.5 Å)