7K13
ACMSD in complex with diflunisal derivative 14
Summary for 7K13
Entry DOI | 10.2210/pdb7k13/pdb |
Descriptor | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION, 2-hydroxy-5-(thiophen-3-yl)benzoic acid, ... (4 entities in total) |
Functional Keywords | fda-approved drugs, nad+, neuropsychiatric disorders, decarboxylase, lyase |
Biological source | Pseudomonas fluorescens |
Total number of polymer chains | 3 |
Total formula weight | 119568.47 |
Authors | |
Primary citation | Yang, Y.,Borel, T.,de Azambuja, F.,Johnson, D.,Sorrentino, J.P.,Udokwu, C.,Davis, I.,Liu, A.,Altman, R.A. Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway. J.Med.Chem., 64:797-811, 2021 Cited by PubMed: 33369426DOI: 10.1021/acs.jmedchem.0c01762 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)